ORGENTEC Autoimmunity Blog

Covering Autoimmune Diseases

anti-TG

New Guidelines for the Diagnosis of Celiac Disease

Celiac disease diagnostics revised 

Anti-endomysial antibodies on monkey esophagus

Anti-endomysial antibodies on monkey esophagus

The diagnostic criteria for celiac disease (CD) have remained unchanged for more than 20 years, after the 1990 revision of the guidelines originally formulated in 1969.  During this period the disease has been intensively studied and scientific findings have unveiled the genetic background of celiac disease, linked to the human leukocyte antigen (HLA)-DQ2 and HLA-DQ8 haplotypes. The key autoantigen tissue transglutaminase (tTG) has been identified and reliable laboratory tests for disease specific autoantibodies now contribute to diagnostics and complement the methodological repertoire of clinical observations and histologic findings in duodenal biopsy samples. Finally, the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) has now published New Guidelines for the Diagnosis of Celiac Disease.

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Research Update: Hashimoto Thyroiditis, APS and Lupus

Lupus and APS – an indicator of increased risk of autoimmune thyroid disease?

It has been known for some time that Hashimoto thyroiditis, also known as autoimmune thyroid disease, can occur together with other autoimmune diseases. For the first time, a study has scientifically established the relationship between Hashimoto thyroiditis and antiphospholipid syndrome (APS).

Today I have taken a more thorough look at this study for you. Although the study isn’t hot off the press, I find the results to be so interesting that I would like to pass them along to you. (more…)

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