ORGENTEC Autoimmunity Blog

Covering Autoimmune Diseases

biomarker

Cutting-edge research for biomarker discovery in rheumatoid arthritis

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Towards Early diagnosis and biomarker validation in Arthritis Management

EuroTEAM Arthritis (Towards Early diagnosis and biomarker validation in Arthritis Management) is a challenging research project, funded by the European Union with 5.77 Million Euro for four years. Clinicians and lab scientists with world class expertise in rheumatoid arthritis research from 13 renowned European research institutions and three industrial partners with competence in design and development of diagnostic test kits for autoimmune diseases, local gene therapy for rheumatic diseases, and human genome analysis join their efforts in the discovery of novel biomarkers for early detection of rheumatoid arthritis. The EuroTEAM members intend to develop approaches to predict the onset of rheumatoid arthritis in people who do not yet have the disease. Ultimately, this will help in the development of treatments to prevent people from getting rheumatoid arthritis.

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Biomarkers for disease activity in Crohn’s disease

May measuring of fecal calprotectin replace colonoscopy for follow up of patients with Crohn’s disease after surgery?

After intestinal resection patients with Crohn’s disease need close monitoring and tailored therapy adjustment to reduce the risk of relapses. Today, colonoscopy is still the gold standard for the detection of disease reactivation, an invasive procedure which is unpleasant for the patient and expensive for the health care systems.

Crohn's Disease

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Biomarkers in blood or stool samples that correlate with endoscopic findings could therefor improve the surveillance of patients with inflammatory bowel diseases.

A candidate marker for this purpose is measurement of calprotectin concentrations in stool samples from affected patients.

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Biomarkers – The Key to Prevention and Early Detection of Disease

Biomarkers are the key to prevention and early detection of disease …

… of this I am convinced. And I am firmly convinced that laboratory diagnostics and the use of biomarkers will have a critical effect on the medicine of tomorrow.

Why am I so sure of this? It has already been demonstrated that biomarkers can be used to optimize treatment for individual patients with diabetes. In the future, individualized medicine (also sometimes called “personalized medicine”) will not only significantly increase the efficiency of treatment; it will also greatly improve prevention and early detection. Today it is already possible to carry out a diagnosis in the symptom-free phase of a disease by using biomarkers. This is of great benefit to the patients who receive early and targeted treatment. (more…)

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