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New Guidelines for the Diagnosis of Celiac Disease

Celiac disease diagnostics revised 

Anti-endomysial antibodies on monkey esophagus

Anti-endomysial antibodies on monkey esophagus

The diagnostic criteria for celiac disease (CD) have remained unchanged for more than 20 years, after the 1990 revision of the guidelines originally formulated in 1969.  During this period the disease has been intensively studied and scientific findings have unveiled the genetic background of celiac disease, linked to the human leukocyte antigen (HLA)-DQ2 and HLA-DQ8 haplotypes. The key autoantigen tissue transglutaminase (tTG) has been identified and reliable laboratory tests for disease specific autoantibodies now contribute to diagnostics and complement the methodological repertoire of clinical observations and histologic findings in duodenal biopsy samples. Finally, the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) has now published New Guidelines for the Diagnosis of Celiac Disease.

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The 2010 ACR – EULAR Rheumatoid Arthritis Classification Criteria in brief

In the September issues of their journals Arthritis and Rheumatism and Annals of the Rheumatic Diseases the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) present a new set of criteria for the classification of rheumatoid arthritis (RA).

Why do wee need “new” criteria for the classification of RA?

The 1987 ACR criteria have been criticised for their lack of sensitivity, especially in early disease. They rather describe the symptoms of fully developed late-stage RA. During the past decade, RA treatment has undergone dramatic changes (more…)

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