ORGENTEC Autoimmunity Blog

Covering Autoimmune Diseases

Ribonucleoprotein antibodies (anti-RNP)

Ribonucleoprotein antibodies (anti-RNP) are antinuclear antibodies (ANA) belonging to the extractable nuclear antigen antibodies (ENA) subset. Anti-RNP antibodies are directed against the U1-ribonucleoprotein of the ribonucleoprotein multienzyme complex.

The presence of specific antibodies to U1-RNP can help confirm a suspected diagnosis of an autoimmune disease: Anti-RNP tests are positive in 95-100% of sera from patients with mixed connective tissue disease (MCTD). However, some patients with systemic lupus erythematosus (SLE) and systemic sclerosis may also test positive for anti-RNP.

Antibodies to RNP-70, the 70 kDa protein of the U1-RNP complex show the highest diagnostic sensitivity for MCTD, their absence completely rules out this disease. Up to 32% of patients with SLE and up to 10% of patients with systemic scleroderma present with detectable anti-RNP-70 titers.


Tests offered by ORGENTEC Diagnostika


Anti-RNP/Sm (ORG 511, ORG 211)
Anti-RNP-70 (ORG 632, ORG 232)
ENA-4-Profile (ORG 544)
ENA-6-Profile (ORG 546)
ENAcombi (ORG 514)


Nucleo-9-Line (ORG 711)


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