In 2012 the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has issued diagnostic guidelines for coeliac disease (CD) that should support physicians in accurately diagnosing CD without performing duodenal biopsies in selected patients. These guidelines have now been updated, new clinical evidence for this approach has been implemented and the non-biopsy approach has been evaluated also in asymptomatic children.
Category: celiac disease diagnostics
Celiac disease diagnostics revised
The diagnostic criteria for celiac disease (CD) have remained unchanged for more than 20 years, after the 1990 revision of the guidelines originally formulated in 1969. During this period the disease has been intensively studied and scientific findings have unveiled the genetic background of celiac disease, linked to the human leukocyte antigen (HLA)-DQ2 and HLA-DQ8 haplotypes. The key autoantigen tissue transglutaminase (tTG) has been identified and reliable laboratory tests for disease specific autoantibodies now contribute to diagnostics and complement the methodological repertoire of clinical observations and histologic findings in duodenal biopsy samples. Finally, the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) has now published New Guidelines for the Diagnosis of Celiac Disease.